Molecular biologists at Princeton University created a special version of Quake II that’s played by mice! “Rather than earning points or power-ups, the mice were rewarded with water from a head-side nozzle,” and the harnessed mice walk on floating styrofoam balls — like a treadmill — to navigate the virtual corridors.
For the first time the experiment lets researchers record the responses of the individual neurons associated with spatial navigation. “Such precision may be decisive in determining how cells in the mammalian cortex encode location – our “sense of direction,”" the article notes.
And check out the amazing video!