Another chapter from my book, 50 Things You’re Not Supposed to Know, published in 2003, by Disinfo.
For more on me, please check out The Memory Hole.
The earthshaking news appeared in the medical journal Human Reproduction under the impenetrable headline: “Mitochondria in Human Offspring Derived From Ooplasmic Transplantation.”
The media put the story in heavy rotation for one day, then forgot about it. We all forgot about it.
But the fact remains that the world is now populated by dozens of children who were genetically
engineered. It still sounds like science fiction, yet it’s true.
In the first known application of germline gene therapy — in which an individual’s genes are
changed in a way that can be passed to offspring — doctors at a reproductive facility in New
Jersey announced in March 2001 that nearly 30 healthy babies had been born with DNA from
three people: dad, mom, and a second woman. Fifteen were the product of the fertility clinic, with
the other fifteen or so coming from elsewhere.
The doctors believe that one cause for failure of women to conceive is that their ova contain old
mitochondria (if you don’t remember your high school biology class, mitochondria are the part of
cells that provides energy). These sluggish eggs fail to attach to the uterine wall when fertilized.
In order to soup them up, scientists injected them with mitochondria from a younger woman.
Since mitochondria contain DNA, the kids have the genetic material of all three parties. The DNA
from the “other woman” can even be passed down along the female line.
The big problem is that no one knows what effects this will have on the children or their progeny.
In fact, this substitution of mitochondria hasn’t been studied extensively on animals, never mind
Homo sapiens. The doctors reported that the kids are healthy, but they neglected to mention something crucial. Although the fertility clinic’s technique resulted in fifteen babies, a total of seventeen fetuses had been created.
One of them had been aborted, and the other miscarried.
Why? Both of them had a rare genetic disorder, Turner syndrome, which only strikes females.
Ordinarily, just one in 2,500 females is born with this condition, in which one of the X chromosomes is incomplete or totally missing. Yet two out of these seventeen fetuses had developed it.
If we assume that nine of the fetuses were female (around 50 percent), then two of the nine
female fetuses had this rare condition. Internal documents from the fertility clinic admit that this
amazingly high rate might be due to the ooplasmic transfer.
Even before the revelation about Turner syndrome became known, many experts were appalled
that the technique had been used. A responding article in Human Reproduction said, in a dry
understatement: “Neither the safety nor efficacy of this method has been adequately
investigated.” Ruth Deech, chair of Britain’s Human Fertilization and Embryology Authority, told
the BBC: “There is a risk, not just to the baby, but to future generations which we really can’t
assess at the moment.”
The number of children who have been born as a result of this technique is unknown. The
original article gave the number as “nearly thirty,” but this was in early 2001. At that time, at least
two of the mutant children were already one year old.
Dr. Joseph Cummin, professor emeritus of biology at the University of Western Ontario, says that
no further information about these 30 children has appeared in the medical literature or the
media. As far as additional children born with two mommies and a daddy, Cummin says that a
report out of Norway in 2003 indicated that ooplasmic transfer has been used to correct
mitochondrial disease. He opines: “It seems likely that the transplants are going on, but very, very
quietly in a regulatory vacuum, perhaps.”
Reference: Genetically-Engineered Humans. Barritt, Jason A., et al. “Mitochondria in Human Offspring Derived From Ooplasmic Transplantation.” Human Reproduction, 16.3 (2001), pp 513-6. • Email communication from Dr. Joseph Cummins, 4 June 2003. • “First Cases of Human Germline Genetic Modification Announced.” British Medical Journal 322 (12 May 2001), p 1144. • “Genetically Modified Human Babies?” Australian Broadcasting Corporation, 8 May 2001. • Hawes, S.M., C. Sapienza, and K. E. Latham. “Ooplasmic Donation in Humans: The Potential for Epigenic Modifications.” Human Reproduction 17.4 (2002), 850-2. • Hill, Amelia. “Horror at ‘Three Parent Foetus’ Gene Disorders.” Observer (London), 20 May 2001.