DMT Use Skyrockets Among American Users

Dmt ideaDisinfonaut DMT tales welcome in the comments! Addiction and recovery site The Fix takes an interest because “Despite powerful hallucinogenic effects and intense vomiting among users, DMT has also been seen as an alternative treatment for addiction”:

DMT, a powerful hallucinogenic compound used in religious rituals among Amazon tribes, has now become a popular recreational drug among U.S. residents.

According to recent reports by the Global Drug Survey and the National Survey on Drug Use and Health, the number of people in the U.S. who have used DMT in some form has risen every year since 2006, with over a million users reported in 2012. The drug is a key component in ayahuasca brew, a combination of two plants grown in South America that has been used as a medicinal and religious aid for tribal peoples in the region for countless years.

One of the plants in the brew, Psychotria viridis, contains dimethyltryptamine, or DMT, which is a common element in many plants and even the human body itself, which neutralizes the potency of the drug. However, when combined with Banisteriopsis caapi, which prevents the body from warding off the drug, the brew – known as yage to Beat literature aficionados who were introduced to it in Allen Ginsberg and William Burroughs’ The Yage Letters (1963) – produces intense and long-lasting hallucinations that users profiled in the Global Drug Survey have cited as stronger than ketamine or LSD. Physical reaction to the drug is also often ferocious, with violent vomiting and gastrointestinal distress among the immediate symptoms.

Despite these issues, ayahuasca has cited by independent scientists and researchers as an effective alternative treatment for addiction, due in part to its ability to raise the levels of serotonin transporters, which regulate mood. Its efficacy in this regard has been hampered by the U.S. Controlled Substances Act, which lists dimethltryptamine as a Schedule 1 drug alongside LSD, marijuana, MDMA, and GHB…

[continues at The Fix]

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  • lunasea

    I’ve always wondered, why, exactly, couldn’t one just take the Banisteriopsis caapi or analogue and trip on one’s own DMT?

    • Durk Westra

      Only thing i could think of is that (the release of) DMT perhaps might be connected to the dreamstate so then one could try to take a MAO inhibitor before sleeping.Hopefully one could remember afterwards if it did enhance the dream experience,or maybe it would facilitate lucid dreaming.Never tried it like that but i do know that MAO inhibitors don’t go well together with certain foods and medicines/drugs so one needs to be well-informed and prepared beforehand.

    • Calypso_1

      You wouldn’t need a MAO inhibitor for endogenous DMT. It’s only because of high levels of MAO enzymes in the digestive tract that oral uptake in prevented. That is why you do not need one for smoked, insufflation or IV/IM. All available evidence shows very little DMT produced by the body. If you you were to take an MAOI to prevent breakdown, you would also be doing the same to all your other catecholamine and monamine neurotransmitters. The effects of which, given higher concentrations, would be more pronounced.
      Now if/when the actual biochemical pathway for DMT is pharmacologically targeted, then it will get fun.

      • jnana

        is there even direct evidence that DMT is produced endogenously? I’m still skeptical of this claim. I’ve heard that DMT is released at birth, death, during dreaming, and during mystical and other hallucinogenic experiences. Now, I’ve yet to try DMT, nor do I consciously remember birth and death, but my experiences of dreaming, including lucid dreaming, and the mystical experiences I’ve had, seem nothing like what I’ve heard about the DMT experience.
        I don’t know but I have an intuition that if there even is any endogenous DMT in the human it probably has little impact on us. If there is any impact, it might be related to some afterlife experiences and, perhaps, speaking with spirits of the dead. Maybe some individuals are more sensitive to DMT, have more endogenous DMT or can intentionally produce more DMT(although those shamans may not conceive of it like that)

        • Calypso_1

          There is but primarily in non-CNS organs, for which it’s function is unknown. It’s not known if it’s a metabolite in a bigger pathway or active in its own right. It’s been isolated in rat brains in very small quantities but there have been difficulties in replicating those experiments. Most of the speculation is based on the availability of precursors and enzymes that could produce it. Given that scenario genetically engineering a pathway is quite conceivable.

          • jnana

            What does it mean when you say it may be a metabolite in a bigger pathway? What would it metabolize? And is it possible that it could have both uses?

          • Calypso_1

            It could simply be a molecule that forms as part of a longer chain of reactions, not actually being of primary significance for the purpose of the reaction. A transition state, waste product, inefficiency (or higher efficiency) given certain base products. To say what it would ‘metabolize’ is a little difficult to answer without delving into biochemistry. Molecules in the body are always being added to, cleaved, joined, systems within systems, interlinked to further systems. By ‘metabolize’, ‘metabolite’, I am simply referring to its place within a reaction as an active component or byproduct. These events can occur within nanoseconds for an active component. If it is a byproduct it is going to float around until it is filtered out or is broken down by some further process.
            Nature is highly conservative in all of its metabolic reactions, so yes it could very well have function, even if it is not a primary one or one involved in consciousness.

    • Yūgen

      You can trip very hard off of banisteriopsis caapi or syrian rue alone, without a dmt containing plant, but this is probably almost exclusively due to the psychedelic affects of the beta-carbolines (maoi) in it. The concentrations of dmt in the brain aren’t usually in high enough doses to be psychoactive, but there is techniques you can learn to enter similar states without ingesting it.

    • jnana

      an interesting sidenote concerning the herbal maoi, Syrian rue, is that one of the active alkaloids was originally called Telepathine because it supposedly facilitated telepathy(in a laboratory setting mind you) between people who ingested it.

  • The Well Dressed Man

    The Well Dressed Man is apparently immune to the glass pipe version. Will follow up after going through the old school ayahuasca ordeal.

    • Monkey See Monkey Do

      Me too. Try Changa. I think its better than ayahuasca.

    • InfvoCuernos

      I’ve heard of a lot of people with that problem; someone who is definitely not me had a similar issue, but as it turns out, it was just inexperience with smoking out of a pizo. Apparently there is a trick to it. After many unsuccessful tries, all of a sudden, BAM! Digital universe, complete with the DMT fucking with the tinnitus and making it cut in and out like a telegram type oscillation(so I hear). I don’t think it would be prudent to go into too much detail, but the answer is on the internet.

      • Monkey See Monkey Do

        No doubt you can breakthrough rapidly and with alot of clarity on crystal, but smoking crystal is pretty harsh so it stops a lot of people from getting big doses. It also has such a rapid take off and landing that a lot of what is experienced is lost to astonishment. Smoking changa can lengthen the experience and remain as visually powerful as crystal. The more you adjust the MAOI and DMT amount in the mixture the more powerful and lengthy it can be. You can launch off into the digital universe for up to an hour long, with as much clarity and power as just pure crystal.

        • Yūgen

          Yes, Changa is the way.

          If you do it right, it will not be even harsh…and can taste amazing….Or so i’m told by swim

        • demetrismaze

          layer the crystal between a herbal blend of bitter herbs like calea zacatechichi and wild lettuce, and I guarantee an easier taste and smoother smoke.

  • Jonas Planck

    I’m guessing the experience isn’t the same without the wizened native spirit guide who might or might not be a ghost.

  • Monkey See Monkey Do

    Or you could smoke a big pipe of changa as soon as you wake up from a lucid dream and go back and explore.

  • Juan

    I thought I was a pretty well seasond psychonaut. But, I had not heard of Changa until just now, from the comments in this post. Looks interesting. Thanks:)

    A quick search turned up the following:

    http://realitysandwich.com/48629/changa_evolution_ayahuasca/

  • jnana

    Although DMT interests me, I have yet to try it, either through crystal form or ayahuasca. I have partaken in many of the entheogens the earth has provided and some that man has synthesized, but there is something about DMT that keeps me from trying it. I’m afraid of it, quite honestly.
    I think entheogens are useful because they destabilize the ego and usual worldview, which helps one to view reality in a different light, which allows for old patterns and habits to be changed. They are especially useful when one is in a rut and/or in need of direction and guidance. But, there is a possibility of a new perception to be imposed on one that is not conducive to well-being. This might be caused by a spiritual invader using the entheogen experience as an opportunity to take over a weak or ignorant individual’s mind.
    Soooo, my spiritual practice has been kinda weak, and that’s why I don’t feel ready for ayahuasca.(although, that may also be a reason to partake)

  • Yūgen

    Btw, the best source on the web for information about DMT is the DMT-Nexus

  • echar

    In my late teens, I smoked peyote. It was a mild trip and I remember feeling good. I’ve yet to try DMT or this new Changa. I am interested, yet cautious. Salvia fucked with my sense of hearing for aproximately a week. I didn’t care for that side effect.

  • Yūgen

    The best source on the web for information surrounding DMT is the DMT-Nexus, just fyi.

    (I thought I posted this earlier but it didn’t appear)

  • dumbsaint

    I spent the latter half of one year dabbling. I’m a bit of a tool so I was typically unmeasured with my doses. At low doses there’s a nice euphoria, cleaner than something like mdma. At higher doses vision becomes distorted, taking on a kaleidoscopic bent. Things like dead grass on lawn form an orderly pattern. It you take the ‘right’ dose the world melts away. It’s really indescribable. My anxiety about dosing right probably screwed many of my trips, leaving me off guard and occasionally turning things horrifying. Can’t recommend being cavalier with it.

  • Matthew Kinne

    Oh, the irony.