Tag Archives | Dopamine

Epigenetic Tie to Neuropsychiatric Disorders Found

2D structure of neurotransmitter dopamine. Created with BKChem and Extensible SVG Optimiser

2D structure of neurotransmitter dopamine. Created with BKChem and Extensible SVG Optimiser

Could this discovery lead to the end of “treating” mental illness through the endless prescribing of psychiatric drugs?

Via ScienceDaily:

Dysfunction in dopamine signaling profoundly changes the activity level of about 2,000 genes in the brain’s prefrontal cortex and may be an underlying cause of certain complex neuropsychiatric disorders, such as schizophrenia, according to UC Irvine scientists.

This epigenetic alteration of gene activity in brain cells that receive this neurotransmitter showed for the first time that dopamine deficiencies can affect a variety of behavioral and physiological functions regulated in the prefrontal cortex.

The study, led by Emiliana Borrelli, a UCI professor of microbiology & molecular genetics, appears online in the journal Molecular Psychiatry.

“Our work presents new leads to understanding neuropsychiatric disorders,” Borrelli said. “Genes previously linked to schizophrenia seem to be dependent on the controlled release of dopamine at specific locations in the brain.

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Are you a Neuro-Throwback?

Throwback

I once had a sled dog team in Northern Minnesota. It was a fairly short lived experience but the strong bond I formed with my dogs brings back powerful memories. We trained together by day exploring the Northern Wilderness, and howled at the moon by night.  When the snow begins to fall very year, I miss it.

A couple of winters ago, I attended a sled dog sprint race in the Adirondack mountains of New York. I walked around and checked out all the participants dogs as usually did and I was unimpressed. The sport of sprint racing had evolved way past its roots in indigenous arctic travel and become a thing in itself. Now, as then, it is no longer a sport for rugged huskies, but rather a competition between sleek mongrel hounds running on perfectly groomed trails. They achieve impressive speeds, but the chain between these hounds and their trapline running forebears seems to have been broken forever.… Read the rest

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