Fr. Troy Pierce writes at the Path of Gnosis:
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One of the common misunderstandings when you tell people that you are a Gnostic is that they hear the more familiar word “Agnostic.” (This becomes quite amusing when they mishear “Agnostic Priest,” or “Agnostic Eucharist.”) This becomes a good opportunity to elucidate one of the truisms of contemporary Gnosticism: You have to be an Agnostic before you can become a Gnostic.
The original differences between agnostic and gnostic are the “privative alpha” of Classical Greek. This prefix functioned like “un-” or “non-” and thus linguistically the two words are opposites, literally ‘Knower’ and ‘Un-Knower.’ (incidentally, the “a” was the first syllable, and the “g” was pronounced in both.)
However, this is Modern English and not Classical Greek, and so both terms have come to have certain more specific meanings. An Agnostic has been jokingly called a “cowardly Atheist,” but is generally someone who knows that they do not know about the divine from the reports of others.