via Live Science:
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Humans have been ingesting mind-altering substances for a very long time. Hallucinogen-huffing bowls 2,500 years old have been found on islands in the Lesser Antilles, and traditional cultures from the Americas to Africa use hallucinogenic substances for spiritual purposes. Here are some notable substances that send the mind tripping.
LSD is commonly known as “acid,” but its scientific name is a mouthful: lysergic acid diethylamaide. The drug was first synthesized in 1938 from a chemical called ergotamine. Ergotamine, in turn, is produced by a grain fungus that grow on rye.
LSD was originally produced by a pharmaceutical company under the name Delysid, but it got a bad reputation in the 1950s when the CIA decided to research its effects on mind control. The test subjects of the CIA project MKULTRA proved very difficult to control indeed, and many, like counter-culture writer Ken Kesey, started taking the drug for fun(and for their own form of 1960s enlightenment).