Via PBS, a fascinating tour around the globe of societies which did not or do not recognize a male-female gender binary:
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On nearly every continent, and for all of recorded history, thriving cultures have recognized, revered, and integrated more than two genders. Terms such as transgender and gay are strictly new constructs that assume three things: that there are only two sexes (male/female), as many as two sexualities (gay/straight), and only two genders (man/woman).
Skoptsy were a Christian religious sect with extreme views on sex and gender. The community, discovered in 1771 in Western Russia, believed that Adam and Eve had had halves of the forbidden fruit grafted onto their bodies in the form of testicles and breasts. Therefore, they routinely castrated male children and amputated the breasts of women to return themselves the the state prior to original sin. Sex, vanity, beauty, and lust were considered the root of evil.