Tag Archives | mouse

Mouse Heart Made to Beat Again with Human Cells

Happy-Valentine-s-Day-Mouse-9780061804328Dr. Herbert West was unavailable for comment at the time of publication.

Via E! Science News:

For the first time, a mouse heart was able to contract and beat again after its own cells were stripped and replaced with human heart precursor cells, said scientists from the University of Pittsburgh School of Medicine. The findings, reported online today in Nature Communications, show the promise that regenerating a functional organ by placing human induced pluripotent stem (iPS) cells — which could be personalized for the recipient — in a three-dimensional scaffold could have for transplantation, drug testing models and understanding heart development.

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Inside the Mutant Mouse Industry That Supplies Science Laboratories

White mice don’t grow on trees. At least, for now.

Pic: RAMA (CC)

Pic: RAMA (CC)

Via New Scientist:

It’s often said that in a city, you’re never far from a rat. Today’s UK government figures for the numbers of laboratory animals used annually in England, Scotland and Wales reveals the extent to which researchers, too, are surrounded by rats and other rodents. In all 4 million animals were used, a 9 per cent increase on 2011. Most of these – 3.3 million – were rodents. Some 2200 primates were used, mainly in pharmaceutical safety tests.

The majority of the rodents – 1.77 million mice – were mutant, “knockout” mice: animals with a specific gene turned off, helping scientists to understand what that gene does. “It’s a bit like trying to understand a car engine without a plan – piece by piece you pull parts out and then see how this contributes to the car not working,” says David Adams of the Wellcome Trust Sanger Institute in Cambridge, UK.

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