Could it be that we’re treating the wrong part of the brain?
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A new study is challenging the relationship between depression and an imbalance of serotonin levels in the brain, and brings into doubt how depression has been treated in the U.S. over the past 20 years.
Researchers at the John D. Dingell VA Medical Center and Wayne State University School of Medicine in Detroit have bred mice that cannot produce serotonin in their brains, which should theoretically make them always depressed. But researchers instead found that the mice showed no signs of depression, but instead acted aggressively and exhibited compulsive personality traits.
This study backs recent research that indicates that selective serotonin reuptake inhibitors, or SSRIs, may not be effective in lifting people out of depression. These commonly used antidepressants, such as Prozac, Paxil, Celexa, Zoloft, and Lexapro, are taken by some 10% of the U.S.