People who report leading happy but meaningless lives experience unhealthy genetic changes similar to those found in the chronically stressed. Via the Atlantic, Emily Esfahani Smith writes:
Many studies have noted the connection between a happy mind and a healthy body — the happier you are, the better health outcomes we seem to have.
But a new study, just published in the Proceedings of the National Academy of Sciences, challenges that picture. It specifically explored the difference between a meaningful life and a happy life, on the biological level.
Researchers Cole and Fredrickson found that people who are happy but have little to no sense of meaning in their lives have the same gene expression patterns as people who are responding to and enduring chronic adversity. That is, the bodies of these happy people are preparing them for bacterial threats by activating the pro-inflammatory response. Chronic inflammation is, of course, associated with major illnesses like heart disease and various cancers.