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With roughly half of men admitting to having tried marijuana and only a third of women saying the same, it’s no wonder the pothead image throughout society is often a male-dominated one. Is this with good reason? Or are women more private about advertising their weed use? There could be numerous explanations — either way, a recent study in the Drug and Alcohol Dependence journal suggests because of their estrogen levels, women may be more responsive to the key active ingredient in the plant.
In the study, funded by a National Institute on Drug Abuse grant, Washington state psychology professor Rebecca Craft found that female rats are at least 30 percent more sensitive than males to the pain-relieving qualities of THC, which is the ingredient in cannabis that leads to a high. The study also found the females developed a tolerance to THC more quickly.